Supplements that might help
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I have stuck to the "main" categories of supplements, although many others are possible. Particularly those that have had some research with FM in itself, vs just general research. The outcomes vary, and none of them is a "cure", and I highly suggest you research them thoroughly, before you commit to using them, but you may find such things will help, and most of us will take all the help we can get. :)

S-adenosylmethionine (SAMe) mixed results:

"Preliminary research suggests that SAM-e may assist those with Fibromyalgia. In one double-blind study in which people with Fibromyalgia were given supplemental SAM-e showed beneficial effects, such as a decrease in fatigue, pain sensation, and stiffness. Study participants also noted a significant improvement in mood. "

"Notwithstanding, not all studies have reported such beneficial results. Oral Vs injectable, oral tablets, having the best results" Research "Side effects may include dry mouth, nausea, flatulence, diarrhea, headache, anxiety, a feeling of elation, restlessness, and insomnia. For this reason, SAMe should not be taken at night."


"Several studies involving patients with Fibromyalgia suggest that a combination supplement providing magnesium and malic acid can relieve muscle pain. The individuals in these studies, after taking 300-600 mg of magnesium and 1,200-2,400 mg of malic acid each day for eight weeks, reported significant pain relief. And when the magnesium malic acid supplements were secretly switched with dummy pills, the pain returned, indicating that the supplement was in fact helping control the pain." Research...Contradictions and side effects

Vitamin D:

"Some doctors automatically test the vitamin D status of anyone who comes to them with Fibromyalgia, since vitamin D deficiency often mimics a lot of the signs of FM. The deficiency is easily discovered, and is easily cured." Primary means is more sunlight, but supplements have been shown to help.

5-hydroxytryptophan (5-HTP)

"Puttini PS; Caruso I Primary Fibromyalgia syndrome and 5-hydroxy-L-tryptophan: a 90-day open study. Rheumatology Unit, L Sacco Hospital, Milan, Italy. J Int Med Res 1992 Apr;20(2):182-9

ABSTRACT: The efficacy and tolerability of 5-hydroxy-L-tryptophan (5-HTP) were studied in an open 90-day study in 50 patients affected by primary Fibromyalgia syndrome. When all the clinical variables studied throughout the trial (number of tender points, anxiety, pain intensity, quality of sleep, fatigue) were compared with baseline results, they all showed a significant improvement (P less than 0.001).

A total of 15 (30%) patients reported side-effects but only one patient was withdrawn from the treatment for this reason. .... It is concluded that 5-HTP is effective in improving the symptoms of primary Fibromyalgia syndrome and that it maintains its efficacy throughout the 90-day period of treatment. " Article "Potential side effects of 5-HTP include nausea, dizziness, and diarrhea. Rarely, allergic reaction to the supplement may occur."

Vitamin B12 (thiamine)

"... normal values were initially set according to what prevents anemia. This is problematic, however, because the brain and nervous system's needs for vitamin B12 are often much higher than those of the bone marrow. Also, the medical establishment has greatly enjoyed poking fun at the old-time and holistic doctors who gave vitamin B12 shots for fatigue."

"The use of B12 shots, despite "normal" levels, is considered almost a symbol of unscientific, archaic medicine. As noted in an editorial in The New England Journal of Medicine, however, current findings suggest that those old-time doctors may have been right. I suspect, though, that our modern medical establishment will be a little slow to eat crow. " Article "

Generally, when vitamin B12 supplements are taken orally then there is little chance of side effects occurring. Some people choose to take vitamin B12 administered with an injection. This type of ingestion as been associated with the following side effects"

• mild diarrhea
• anxiety and panic attacks
• heart palpitations
• insomnia
• breathing problems
• chest pain
• skin rash, hives or itchy swollen skin

Some health professionals believe that patients develop these reactions not because of the B12, but because of the preservatives that are part of the injection formula. Currently, most injections contain preservatives. To be on the safe side, it is probably better to take B12 orally" Article


"DESIGN: Forty-one (41) patients with a diagnosis of FMS and/or CFS were given D-ribose, ..., at a dose of 5 g t.i.d. for a total of 280 g. All patients completed questionnaires ... and a global assessment pre- and post-D-ribose administration. RESULTS: D-ribose, was well tolerated, resulted in a significant improvement in all ... categories: energy; sleep; mental clarity; pain intensity; and well-being, as well as an improvement in patients' global assessment."

"Approximately 66% of patients experienced significant improvement while on D-ribose, with an average increase in energy on the VAS of 45% and an average improvement in overall well-being of 30% (p < 0.0001). CONCLUSIONS: D-ribose significantly reduced clinical symptoms in patients suffering from Fibromyalgia and chronic fatigue syndrome." Research Reported minor side effects include diarrhea, gastrointestinal discomfort, nausea, and headache.


"An open, pilot study to evaluate the potential benefits of coenzyme Q10 combined with Ginkgo biloba extract in Fibromyalgia syndrome.
Lister RE. J Int Med Res 2002 Mar-Apr;30(2):195-9.An open, uncontrolled study was undertaken to measure the subjective effects of coenzyme Q10 combined with a Ginkgo biloba extract in volunteer subjects with clinically diagnosed Fibromyalgia syndrome. "

"Subjects were given oral doses of 200 mg coenzyme Q10 and 200 mg Ginkgo biloba extract daily for 84 days. A progressive improvement in the quality-of-life scores was observed over the study period and at the end, the scores showed a significant difference from those at the start. This was matched by an improvement in self rating with 64% of Fibromyalgia patients claiming to be better and only 9% claiming to feel worse. Adverse effects were minor." Research ... Contradictions and side effects

Chlorella :

"Each day for 2 months, participants consumed two commercially available Chlorella-based products, 10 g of Sun Chlorella tablets and 100 mL of liquid Wakasa Gold. Any amelioration of symptoms was validated and quantified using semi-objective and subjective outcome measures systematically administered at clinic visits on days 0, 30 and 60 of the diet therapy. "

"Eighteen of the 20 patients enrolled completed the 2 month trial. The average TPI for the group which at onset was 32, decreased to a mean of 25 after 2 months. This decrease was statistically significant (p = 0.01), representing a 22% decrease in pain intensity. Blood samples taken on each occasion indicated no significant alterations in serum chemistries, formed elements, and circulating lymphocyte subsets. " Research ... Do not use Chlorella if you are pregnant or breast feeding.

Acetyl l carnitine:

"One hundred and two patients meeting the American College of Rheumatology criteria for FMS were randomized into the study. The treatment consisted of 2 capsules/day of 500 mg LAC or placebo plus one intramuscular (i.m.) injection of either 500 mg LAC or placebo for 2 weeks. During the following 8 weeks the patients took 3 capsules daily containing either 500 mg LAC or placebo."

"The patients were seen during treatment after 2 (visit 3), 6 (visit 4) and 10 weeks (visit 5). The patients were also visited 4 weeks after treatment discontinuation ... Most VAS scores significantly improved in both groups. A statistically significant between-group difference was observed for depression and muscular-skeletal pain. Significantly larger improvements in SF36 questionnaire were observed in LAC than in placebo group for most parameters. Treatment was well tolerated. 

CONCLUSION:Although this experience deserves further studies, these results indicate that LAC may be of benefit in patients with FMS, providing improvement in pain as well as the general and mental health of these patients. Research

"Side effects ... according to research are rare but may include, vomiting, nausea, headache, diarrhea, stuffy nose, restlessness and sleeping difficulty. Some serious side effects may include fast heartbeat rates, increase in blood pressure and fever. Should not be taken late at night."

DHEA dehydroepiandrosterone: Has been shown not to help

"DHEA is converted into other steroid hormones, including testosterone and estrogen; its levels in the body naturally peak during the 20s and then taper off as people age. DHEA at 50 mg a day for 3 months was given to 52 women, mostly in their 50s and 60s, who had been diagnosed with Fibromyalgia. 

Overall, the women reported no clear improvement in pain, fatigue, depression and anxiety, and physical and mental function -- with either the supplement or the placebo. Journal of Rheumatology, July 5, 2005." Research